The hardest part of Fantasy is getting everyone to agree on a draft date and time, but even that you can line up your picks before hand and let the computer pick for you from your picks.
Usually there are 10 people, but we can get by with 6 people and have plenty of good players to draft. It really isn't that much work and Yahoo has a nice analysis system that gives you advice on who to bench and who to play. The default rules are pretty good also.