You can, but most reports are that upscaled/doubled apps look pretty shitty and most developers are coming out with new, pay for it again, versions for the ipad despite what Steve led people to believe at the product announcement.
If you don't think you need much space on the pad Ryan I'd really think long and hard about the 3G/16GB version. I don't have wifi at work, there are no local hotspots for me, and without web service the capabilities of the iPad are pretty much castrated. Yes the $130 pill is a sucky one to swallow but it'd be worse to end up with a borderline useless $500 device.