Off the top of my head, USB out to a DAC-1 Pre feeding a pair of Dynaudio MC-15 would not suck at about $2,500.
Or the Stello DAC and amp stack plus some Audioengine A5s plus the Headroom stands to put them on for <$2,000. Mix and match as desired.
I can't particularly tout my own system as it's a bit messy. I have the equipment in a shelf off to the side and just the speakers on the desk. There's a thread here where everyone chipped in with advice for me that might help you out, too.