I know I'm a mac noob, but its worth mentioning I have some issues with my Apogee Duet w/ my mac mini (latest version, several months old).
Sounds fine, but occasionally turns to ear piercing digital noise.
Resetting connections via the software doesnt do anything, the only way to fix it is to close itunes, open the midi settings (whatever its called) and click off of 44.1khz, to something else, and then back.
I'm thinking this is because I'm going from the firewire 400 to a firewire 800 adapter, but idk.
I can live with it, but I thought I'd mention it.
I have a drobo 2.0 connected via USB 2.0, which has all the music. I suppose I should move some music onto the internal HD and see if it changes, but the lost connection is sporadic.