That filson one is pretty iffy imho.
I have some sort of tumi, it looks alot like the alpha, though I removed the shoulder straps, as I cant stand them. Its got like 18,000 pockets in it.
I went with leather after having the nylon of my last bag start to wear apart in several corners.
I dont think you'd regret a tumi.
Just mind the width if you're planning on ever hauling a laptop in it, some of them are small.