For anyone wanting to squeeze some more performance out of CP2077, this mod combines a number of fixes into a single package. Highlights include it fixing the bug where the game doesn't use all the threads available on AMD CPUs, and enabling it to make use of more RAM and VRAM than it does out of the box. It won't be a miracle fix for most people, but my frametime lows improved significantly and as a result the game feels way smoother in busy areas.
In addition, Digital Foundry has released their recommended settings guide, which will give a nice bump to average framerate over having everything cranked up, without hurting how good things look. The settings are summarized in the video description so you don't have to watch the whole thing if you don't want to.