Jacob, the Ohio River roads in Indiana I am talking about are the following: Just northwest of Louisville, on the Indiana side of the river, pick up Indiana 62. You'll drive that west for quite a while. Twisty and fun. The times I've been on it there was little traffic and good pavement. You'll then intersect with Indiana 66. Continue west on 66. It pretty much follows the river. Some great twisty bits, good pavement and really nice river views. Things straighten out and get boring as you get closer to Evansville.