The big ones can be intimidating and even painful if you're not ready for the encounter. But if you free your mind and resolve to enjoy the situation, you'll usually find that you can handle it alright.
Al had a huge one in Mayberry, and I don't remember anyone complaining, or getting hurt. In fact I remember Colin smiling the whole time.
The small ones can be easier to the beginner though. They seem to go smoother, though I think that's mostly psychological.
Acidbasement had a really little one in Winnipeg, but I think the four of them still enjoyed it.