Pete Townshends SG + Sound City/Hiwatt rig from The Isle of Wight 1970 is almost unbeatable for me; I don't think you fit more rock into each chord than with that tone.
I also love Michio Kurihara's totally jarring and insane sound in his solo on Boris & Michio Kurihara - Rainbow's title track:
[ame=http://www.youtube.com/watch?v=l1z0FGxWi7Q]YouTube - Boris with Michio Kurihara - Rainbow[/ame]
Jeff Tweedy has kind of a similar effect on "At Least That's What You Said", apparently he was trying to replicate one of his panic attacks on guitar.
Lesse... there's anything by Jimi, especially "Who Knows" off Band of Gypsies, also Eddie Hazel from Funkadelic on the entire album Maggot Brain--totally sweet fuzz/wah stuff.
And on the subject of P-Funk, how about their bassists? Not just Bootsy's filters and tons of effects either, check out Rodney "Skeet" Curtis on "Who Says A Funk Band Can't Play Rock?" Beautiful Alembic tone.
Cecil McBee, who played alot with Pharoah Sanders and a bunch of guys on Strata East has a really earthy, soulful upright sound. Fred Hopkins of Air (the trio w/ Henry Threadgill, not the french dudes) does the opposite but equally well with his totally grinding, vicious plucking.
Rodrigo Y Gabriela probably have my favorite acoustic guitar tone, especially Gabriela's strumming/percussion.
As for Jack White, he has some cool whammy pedal stuff on "Little Cream Soda" on Icky Thump, but really anything with him usually has some cool axemanship.