I have the Rocksmith game but have only played it once. The thing I don't like about it (at least at the beginning is that it doesn't tell you what you are going to playing ahead of time which makes it a bit more like a video game). I find watching you tube videos more helpful. Perhaps there is a bit more to the game than I have seen. I have a friend that is using it to learn to play guitar and loves it.
I do love my (cheapo Korean made) PRS Custom 24 SE guitar. I would love to have a on non-SE one.
But yeah, you're just going to have to go to the store, try some guitars and see how they feel in your hand Jeff.